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Early therapeutic efforts using muscarinic receptor agonists like xanomeline were limited by peripheral side effects

though the first use of the ligand for a brain-targeting prodrug of methotrexate was reported in 1991 [22]

In addition, VRK2 overexpression confers PC cells resistant to ferroptosis induced by exogenous ROS through promoting ER-to-Golgi trafficking of SLC7A11, which echoes the findings that PC cells with high expression of VRK2 have an elevated basal level of GSH

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